The movie industry attempted the first major foray into this realm with the film Beowulf. This was done in the style of Polar Express. They are still lacking the finesse of reality but Star Wars: Rogue One gave it a fairly good shot.
In Avengers Endgame, the animation process used to convert Thor into an obese alcoholic was so well done it was scary. The way they merged Hulk with Ruffalo as well.