Fairly recently a couple of our F22 raptors took on two SU25’s that strayed over the no fly zone in Syria. Then an SU35 got involved and our 22’s ran all 3 of them home.
Using stealth aircraft as interceptors is probably not a good idea. Their strength in A2A is the Beyond-Visual-Range shot. You’re never going to get permission to do that short of a declared war. Also, taking an F-22 into an ACM environment with a SU-35 is rolling the dice. This is why the USAF is going to buy the F-15X. They don’t need stealth for “showing the flag” and warning off Russian planes sniffing around our airspace.
Get enough new F-15 airframes and you can group your F-22’s for offensive action and focus their training instead of having them chase away Russian Tu-95 Bears.