At their height, millions of the vermin swarm through farmland causing tens of millions of dollars worth of damage to infrastructure and livestock.
Bizarrely, the only places in the world to suffer from mice plagues are parts of Australia and a single province in northwest China.
The exact reasons for this remain a mystery, but it is suspected to be linked to the fact mice were introduced to Australia by European settlers and have little natural competition or predators.
Australias Commonwealth Scientific and Industrial Research Organisation research officer Steve Henry warned last year that the countrys mice population can easily spiral out of control.
He told the ABC: Its pretty scary how quickly they can breed up. Its quite concerning.
People in the towns complain if they have one mouse in their house, but when plagues hit rural areas, people have hundreds of mice in their houses.