I had a drink containing appertain. It tasked like metal, but it was more aftertaste than something I noticed right away. I got a headache so bad I had to leave work. I spent the rest of the day in bed. That was the last time I tried an artificial sweetener.
I don’t have an answer to the question, but I would add that I once befriended a couple of Ph.D. chemists who worked in the field.
They confided (emphatically), that none of the artificial sweeteners are good for you. I have avoided them ever since.