Short answer, no.
Longer answer, If you know EVERY micronutrient a human body needs, and can make it in a factory, and you have the industrial ecosystem to feed and repair that factory, the body can be sustained.
Whether a living body with no other living things to interact with is still a human being is an exercise left to the reader.
And are we designed for space travel? Clearly no.
But how much can we do without the complex ecosystem is the question. Scientists and engineers can offer solutions. Maybe humans will have to be modified in some way?
I like to use the analogy of traveling with the wife - do you really need that industrial sized hair dryer? Do you need the three jumbo sized suitcases? No doubt scientists are considering this. But maybe the need to completely rethink it.
There are many aspects of a human being that we don’t even understand yet. Maybe subtle things like the earth’s mag field are necessary.