Fight against one’s chromosomes does not seem to be mentally-stable.
s/b Fighting
Now, when the day comes that some PhD guy can change the chromosome count....the cards will truly be reshuffled. But then, you might discover that you got newer and bigger problems to worry about, and kinda wish you were at back at starting point.
If you look at this via the evolution business...some ape was sitting there one day and realized that junior was no longer a 48 chromosome count...junior had forty-six, and he was a bit different.