As far as the liver is concerned, this "better living through chemistry" world we've created is a tough place to work.
I've seen this first hand while re-learning how to feed my dogs.
My dogs both had some serious health issues that were greatly improved, if not totally resolved, by changing them over to an all organic, whole food, homemade diet that cancer patients are encouraged to follow.
In hindsight, this makes sense to me now. Try it and see for yourself.
Eating food that is as "close to God" as you can get it, and then made with love in your own kitchen, has to be better than the stuff in a can, box or bag that's made by a machine in a factory somewhere with the goal of maximum shelf life as top priority.
Tastes better, too...
My maltapoo had horrible digestive problems. I switched to homemade rice, chicken, livers and sweet potatoes. The difference is amazing. No more tummy issues and she’s gained a full pound in muscle...no small thing for a pup that was 7 pounds to start with. Her vet is amazed with the transformation. Still doesn’t have an ounce of fat on her.