One of my daughters was just talking about Machu Picchu, but I don’t know if I could handle the altitude. I told her we’d go to Rome someday ... but that’s what my mother told me, and we didn’t make it. (Dad was sick, and I had a baby.)
A couple of my church choir members are from Ecuador. Life in the Andes is totally different from what we’re used to, even if the towns look like European civilization. The altitude really makes a difference.
If you can make the trip to Rome, I can’t think of anything to top it. I’ve been to Rome once for the Jubilee in 2000. We spent most of our time around the Vatican (jaw dropping) but ventured to the old Rome center to visit the jail cell of Sts Peter and Paul and visited the catacombs. Nothing tops being in St. Peter’s square and seeing Pope St. John Paul II.