Most people take them wrong. For instance, taking water and oil-soluable vitamins/supplements together harms absorption. Take B alone with water or juice, but D with fish oil, coconut oil, coQ10, etc. Taking B with oil-solubles will almost guarantee it is not absorbed. “Centrum” is essentially useless since all are mixed together.
Some friendly correction. Fat soluable vitamins and oils should be taken with water soluable antioxidents to prevent oxidation and improve activity tiime. In addition, CoQ10 should be taken with vitamin E or oil to improve absorption and vitamin D should be taken with Vitamin K2 to prevent calcium build up in the arteries.