There was a movie about something like this with Julie Andrews and James Garner called “Victor, Victory”.
Then there was the Ed Woods movie “Glen, Glenda” or something like that.
And finally there is the documentary movie of “Michele and Barack: The Gene-Benders of the White House” (produced by Roman Polanski and Oliver Stoned).
In the works, “Hillary The Movie: All You Want to Know About Cackles and Cankles”.