Well, I live in tornado alley (St. Louis) and trailers don't seem to get hit any more often than other dwellings. They may (or may not) be more dangerous when they do get hit, but for the money they are a good deal. I live in a low-income area and I have considered renting one and decided against it - but not because of tornados.
During my college years, I had a job at a mountain resort in a very expensive area, and the resort provided employee housing for that reason. Single wide trailers. Nice enough, all things considered, I couldn’t have afforded to work there if I had to commute 30 miles on steep mountain roads, and forget renting anything nearby. I didn’t mind, the employees who lived there were mostly my age, it was sort of fun. But, I can still remember hearing the aluminum siding and roof rippling and crinkling in high wind, and you could feel it moving. If it weren’t for all the trees providing a wind break, I’m sure some of them would have rolled over in the wind. It was unsettling. I’ve never lived in one since. If circumstance meant I had to, I’d want it on a permanent foundation with substantial tie-downs.