You mean the way the Colonists left the British Union? Sure they can. After all, we did.
I reject your premise. Natural law dictates that people may leave whenever they wish, and for whatever reasons suit them, and they do not have to beg indulgence of others to do so.
“Natural law dictates that people may leave whenever they wish, and for whatever reasons suit them, and they do not have to beg indulgence of others to do so.”
Reductio ad absurdum. What you have defined is anarchy not natural law.
There is not a single significant contributor to the Declaration or 1776 that ever would have penned such a statement. Years of reasons and pleadings and petitions preceeded Lexington and Concord.
Your ignorance of this history is breathtaking.