Remember. Prior to Columbus and the Spanish and Portuguese invasion and conquest of Central and South America, the largest domesticate animal, semi-domesticated anyway, in America was the llama and then in only every limited areas.
Europeans introduced the Horse, yet by the founding of the United States there was a century old Horse culture of native Indians in the Central Planes of America. They almost certainly had no direct contact with Europeans until the first trappers started following Luis and Clark in the early 19th Century.