>> Direct descendant of John Knox (c. 1513 - 1572) <<
I’ve always heard that none of his legitimate children survived long enough to reach their own child-bearing ages.
But some of today’s Knox-surnamed families may descend from one of his brothers or first cousins.
My connection is through the South Carolina branch of the Witherspoon family. The marriage of John Knox's third daughter, Elizabeth, to the rev. John Welsh of Ayr in 1592 is well documented. Their youngest daughter Louise Welsh (b. c. 1613), married James Alexander Witherspoon in Scotland c. 1635. There is some dispute among genealogists about the connection regarding Louise, but it has been part of the family history of the Witherspoon family going back to the early 18th century, and is even mentioned in Boddie's History of Williamsburg, South Carolina.