King George III suffered from this condition. There was a movie made about it: The Madness of King George, I think was the title. I knew a woman with partial Native American ancestry who was suffering from it. Took her many years and much misdiagnosis from doctors and mental health professionals before she finally found out the cause.
Didn’t know it could be serious, guess I should tell my MD about it. One of my aunts told me it ran in the family in case I needed to know but not why I might need to know. I thought I might throw off a compass or something.