We could discuss those rarities, but let’s be realistic.
Realistically there is more mental illness than intersexual abnormalities. None the less, I have known a number of people who have them.
My point is simply to be accurate in what determines sex, and that is the functioning of the endocrine system primarily during gestation.
After the body passes the development stage artificially induced hormonal changes are of limited effectiveness and can pose health hazards.