[Alas Babylon!]

European disease was the biggest destroyer of the people, and that was unintended.

Yes. As many as 90% of Native Americans died of Old World diseases. Most never even saw a white man when they succumbed.

Population history of indigenous peoples of the Americas

[Jay Redhawk]

One estimate had Mexico with a population of 16 million in the year 1520 when the Spanish arrived, and a population of 2 million in 1620 a mere hundred years later. Yes, I bet it is true that most of those dead never even saw a Spaniard before they died.