Were it ridiculous, you could answer it without handwaving.
The Supremacy Clause is pretty straightforward.
It doesn't derogate at all from self-governance, because the Federal government which reviews state acts is elected by the people themselves.
“It doesn’t derogate at all from self-governance, because the Federal government which reviews state acts is elected by the people themselves.”
Of course it does, because if we need to seek permission to exercise a right, then it isn’t a right anymore. That is pretty basic stuff, but I guess I can’t expect you to understand that, since you are a statist.
Yes it is. "to which the Laws of Nature and of Nature's God entitle them". No getting around that. No man made law can stand against the authority of God.