The way those are constructed a few tons of HE in the vaults and then charges to seal the shafts before it was detonated might not bring them down, but they will forever be just a pile of rocks.
They and the sphinx are one of the few things really worth fighting for over there imho.
If Egypt got The Bomb, and jihadists took over (again), I’ve seen it suggested that they’d nuke the Great Pyramid — however, it is too close to Cairo even for jihadists to pull that kind of stupidity. :’) In the case of the Great Pyramid, there’s a subterranean chamber, with a sloped passage leading to it, that would make a nice place to give this a try. But again, one of the most populous urban centers in the world would have to be evac’d first, with nowhere for the residents to go.