Indeed.
The worst I've ever gotten from that is singed. Castle Bravo is the most extreme example I can think of. "We" had a lot to learn. It is instructive to compare today's almost paranoid radiological safety measures to Marie Curie's standard laboratory practice ...
Many of our greatest scientific discoveries have occurred by accident.
The condition Mme Curie was in when she died is a good example of why we have those lab practices ...