Came nose-to-nose with a cow moose once while driving my pickup down a logging road. I suspect that there was a calf somewhere around, because she wasn't going to let me by. So there we sat.
Eventually, she got out of the way, but it took awhile. Wasn't much I could do; she was as big as the truck I was in.
A whitetail buck charged my brother’s truck and put a half dozen holes in his radiator after he brilliantly honked at two bucks fighting it out in the middle of the road.