I regularily take my daughter to UCLA med center, a few miles off the 405 & Wilshire, about 113 miles from home. It’s always a crawl on the 405 from about Van Nuys on. In rush hour it can take over an hour to go the last 15 miles and it doesn’t get better once I get off on Wilshire. I truly hate that place.
Heading home at 3pm, the 405 would already suck, so I'd do Sepulveda until well through the freeway "Sepulveda Impasse".