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If your’e going to kill her, there are much easier ways than taking out a whole plane. Second, this supposed plot would involve the plane crashing, and one of the survivors killing her. if someone on the plane was in on the plot, why would they consent to being on a crashed plane with the chance of getting killed themselves?

I'm not saying I believe it, but I don't see why someone on the plane needs to be involved.

In the airport, Fuddy is injected, or ingests a toxin that will eventually cause her heart to stop. You would want to administer the toxin when certain that Fuddy was going to be on the plane. Maybe someone walks up to her as her flight is boarding, and thanks her for helping them with something, and simply wants to shake her hand. The toxin does not work immediately - that would result in either medical attention right there at the airport, and a person not diagnosed with a heart condition dying of a sudden heart stoppage, of unknown cause, might raise suspicion. Since the toxin takes awhile to work, and to insure that she can't be rushed to a hospital, the engine of the plane she is about to board is sabotaged. If the plane crashes catastrophically that is ok, and if the pilot is able to make a successful water landing, that too is ok. As long as medical attention can not be provided during the required period that is all that would be required.

The toxin guarantees that Fuddy will not survive, and the plane insures that medical personnel are not able to document her death. No one need be involved accept the person who administers the toxin to Fuddy, and sabotages the engine. Only one or two people, very simple, and very easy.

Also, I forgot one main thing.

If Fuddy was killed, it would be imperative that she not survive, and if the method of killing her was not immediate, that she not know that she was being killed.

Why? Simple, if someone did kill her, it's safe to say that it was because she had damaging information. And if that is true, and she became aware that someone was trying to kill her, I think it's also safe to say that she might decide to pass that damaging information onto someone around her.

The toxin guarantees that Fuddy will not survive, and the plane insures that medical personnel are not able to document her death. No one need be involved accept the person who administers the toxin to Fuddy, and sabotages the engine. Only one or two people, very simple, and very easy.

One person too many.

There's a four-letter agency which is very interested in failing airplane engines. They investigate very thoroughly and take the better part of a year to cough up their findings. And there's a three-letter agency they call if they find signs of foul play.

If you are a competent assassin, why would you risk their involvement, when a Bushmaster is all you'd need?