Yeah William Atherton "dickless" has made a career out of being great at unlikeable characters.
So was Paul Gleason, (RIP) also from Die Hard and the Breakfast Club.
Now that I think about it I hated James Spader in Pretty in Pink.
Good actor in other roles, though.
3 choices:
1) Anybody who portrays Obama
2) Anybody who portrays Hillary
3) Anybody who portrays Pelosi
Close seconds are:
"Hey, sprechen ze talk?"
Lot's of characters played by Gary Oldman 
Amon Goeth
Why so serious?
Anton Chigurh--" What's the most you ever lost on a coin toss? "