Yes, it is. My husband's friend felt lousy and sick for years. He had been sick so long that he didn't realize he was sick. His daughter started experiencing similar problems and got tested. She's got Celiac. The friend started eating a gluten-free diet and was amazed by how good he feels now. IF you've got a problem, it can really be a huge quality of life issue.
My son is autistic and has been gf for years. Last year, I gave it up for Lent, just for Lent. My headaches cut in half, but not only that, my prematurely always swollen ankles disappeared. My husband noticed and said, “don’t go back.” Less brain fog, more energy, and I lost about 5 lbs without trying (this was not my goal.) When I have accidentally had gluten, I get stomach problems, a headache, and yes, cankles.