Well, if you consider being dead a benefit over being alive, as is true of the millions that died of disease.
Of course, the disease deaths (which exceeded the actual killings of native Americans probably by a factor of 10) weren't deliberate, and they would have happened even if the Europeans had visited in small numbers to conduct multicultural diversity seminars and then left; of course there was no understanding at the time of how infectious disease was transmitted, either.
The destruction of nearly all of the New World Amerindians by pandemics of disease was also destined to happen when a an Amerindian civilization eventually attempted to colonize and conquer and enslave people in the Old World.