Why anyone should concider opening a business in SF is beyond me, unless, of course, the company is “progressive” and if so, they can suck-it-up, and the patrons as well.
Well if you wanted to open a "men only" communal bath house bid'ness I am thinking opening in San Fran would be the best plan!
Maybe a medical business which focuses on certain men’s issues would do well? One which treats afflications often found in gay men?