It is practically impossible to prove anything in physics 100% conclusively. But there are theories of varying certainty based on quantifiable observations and experiments.
For example, there is a good deal of observable evidence of a “Big Bang”. Direction, velocity, and acceleration of galaxies can be determined. It paints a picture of a high energy event originating from one point with the relative intensity of an explosion. What exactly was that event and what caused it? We may never know since it was way before our time.
There is also observable evidence that the universe is like an energy pendulum, eventually imploding into a single black hole or many black holes. At each galaxy, there is a giant super black hole at the center. Perhaps there is a critical point where the energy absorbed by the black hole is once again released as mass to implode and create yet another universe. That can only be studied on paper for now.
But as far as an intelligent, deliberate Deity goes? We don't have a single piece of observable evidence or any experiments that show this possibility. It's not that most people in the scientific community don't want to admit God exists. There just has to be at least something tangible to point in that direction. A book written by man with no extraterrestrial qualities is not scientific evidence. Perhaps such a book did exist but there is nothing tangible that says it ever did.
Well, FWIW, the scriptures explain that God “stretched out” the heavens, and that he created the earth before the sun moon and stars. Scripture also explains that the creation is “wearing out like a garment”, which God will roll up like a scroll. Written over 2000 years ago, well before the telescope and Doppler theory were developed. This is also a reasonable explanation for the observations we make today. No human was present at creation to observe it, and we tend to dismiss eyewitness testimony anyway, so any explanation of origins is conjecture, requiring faith on the part of the adherents. Want proof of God? Honestly consider the claims of Jesus, and the proofs of his resurrection. If he rose...