Giffords was going to face a tough re-election in 02. The election campaign in 00 was tough enough. Right now the question of redistricting is up in the air, but its possible that the new lines drawn, to ensure that Marxist Raul Grijalva keeps his seat, would be detrimental to her.
I wish Giffords well, but the fact is that she was in a dead heat election and was only very narrowly re elected. She killed her previous broad base of support due to her party line support of the Obama/ Pelosi/Reid Democrat legislative cram down during the first two years of Obama.
Tucson is very liberal but it has yet to transition from liberal to hard left in most areas of town and a lot of otherwise liberal people were turned off by the hard left positions she supported. Tucson's huge retired population was not thrilled with ObamaCare, heath care rationing and death panels
It's likely she only won due to vote irregularities and fraud, mostly in the illegal alien community, pulling her across the finish line.
The whole reason why,in the first place, she scheduled the public meeting where she was shot was to start a charm offensive to try to re build the bridges she burned with a large segment of the electorate in her district during the first two years of the Obama Administration