Well, in the case of physics, I think a lot of practitioners have reached the point of putting too much faith in their equations, and not doing an adequate job of experimentation.
In the case of biologist,ecologists, "climate researchers", I think they have put their "feelings" for "unspoiled nature" ahead of their science, often to the point of out and out fraud (lynx hair incident)
With Experiments, you have to explain what you are observing.
The least fantastical explanation is usually correct. In any case, you must be able to mathematically describe your theory to demonstrate it is at least probable. Math doesn’t lie, if your theory is correct, it fits like a jig saw puzzle into place.
With LENR type experiments, you have a reaction without a theory. LENR was the only theory attempted although discarded buy others. People are coming out with new theories all the time that can be tested against the observations.