I came up with the hypothesis when I considered that they only made Clovis points for a time and then they went back to making easier spear points. Of course, the fluting helps in attaching the point to a shaft. However, there is no sign that they had too much trouble attaching later points to the shaft either.
They could test my hypothesis by looking for toxins in the flutes. Maybe a few molecules remain.
I still think that Clovis points had something to do with the extinction of the megafauna. There is certainly a temporal connection.
As for the disease hypothesis, it would be unusual if one parasite or pathogen wiped out multiple species.