If one really takes the time to look through the literature it becomes fairly clear that the hyper-stimulation of the hypothalamus gland can cause damage to the gland causing it to shrink or change structure while causing individuals to need larger and larger doses of naturally occurring sex hormones involved in natural sex bonding. Just insulin receptors can be desensitized it is clear a similar thing can happen involving sex which can led to depression, other addictions, abnormal sex bonds, increasingly risky sexual behavior to achieve the sexual high.
I don't think it is strange that some studies show homosexuals have morphological changes in their hypothalamus being somewhat smaller. What you one isn't often told is that a study in rats showed that when a group of male rats were divided into two groups one which was presented with an endless string of females in heat while the other group disinterested females that the group of hyper-sexed males had significantly smaller hypothalamus regions at the end of the experiment where as before the experiment they did not. I suspect you'd find the exact same thing in sex addicts, and other sexually disordered populations.
And it starts with parents and children being told that masturbation is perfectly harmless and natural. It is the first step in setting people up psychologically to associate sex as empty pleasure devoid of human interaction. It also may be a precursor to homosexuality as it is sexual pleasure acquired through same sex (self) manipulation.