For a thread that gets right to the heart of the problem of taking a moderate sized animal and breeding it up to where it’s among the other animals, try this thread: http://www.freerepublic.com/focus/f-chat/2598013/posts
We need to take a long hard look at a race horse before anyone starts throwing around the idea of selective breeding of humans.
Gattica hit the nail on the head with this, these supposedly superior humans were also non aggressive, and just couldn't seem to compete with normal humans - heart defects and all.