“The complications of both types of diabetes are very similar.”
I believe I said something similar in this thread.
“This is, “a multicenter, randomized, double-blind, placebo-controlled trial.””
I am a lay person. 238 is a small number for a study of this kind.
“...failed to validate the homocysteine hypothesis ..”
Ah, ok. That is not what is important to me as a female with Type II history in my mom’s family. Besides, there is already a history in her family of an increase in “vascular events”. Most of them have had heart surgery without taking B vitamins. That would be nothing new for my families history. The only sibling who hasn’t had heart surgery gave blood most of her life to help others with RH negative blood. Maybe there was something to all that blood letting thing after all.
Don't think like you should expect sample sizes similar to the sizes used in political polls. It's apples and oranges to compare political and scientific sample sizes. These results are also expressed in terms of probability using the term 'P'. Here's the results:
"Results The mean (SD) follow-up during the trial was 31.9 (14.4) months. At 36 months, radionuclide GFR decreased by a mean (SE) of 16.5 (1.7) mL/min/1.73 m2 in the B-vitamin group compared with 10.7 (1.7) mL/min/1.73 m2 in the placebo group (mean difference, –5.8; 95% confidence interval [CI], –10.6 to –1.1; P = .02). There was no difference in requirement of dialysis (hazard ratio [HR], 1.1; 95% CI, 0.4-2.6; P = .88). The composite outcome occurred more often in the B-vitamin group (HR, 2.0; 95% CI, 1.0-4.0; P = .04). Plasma total homocysteine decreased by a mean (SE) of 2.2 (0.4) µmol/L at 36 months in the B-vitamin group compared with a mean (SE) increase of 2.6 (0.4) µmol/L in the placebo group (mean difference, –4.8; 95% CI, –6.1 to –3.7; P < .001, in favor of B vitamins)."
P = .02 means that you expect that result 2 times out of 100 just by chance
P = .88 means that you expect that result 88 times out of 100 just by chance
P = .04 means that you expect that result 4 times out of 100 just by chance
P < .001 means that you expect that result less than 1 time out of 1000 just by chance.
At most these mega doses of B Vitamins didn't help. The numbers scream obvious harm. Check out the null hypothesis in any search engine.