I suspect a lowly .410 shotgun loaded with bird shot would do the trick. One shot for each eyeball... but I wouldn't want to test that theory with my life.
There’s no purpose for a 410 shotgun which involves killing anything other than possibly for rats. The 410 is for perfecting skeet shooting skills. That Marlin lever-action 45/70 with heavy ammo really is Amnerica’s most lethal gun. It can drive a bullet straight through a cape buffalo or rhino sidewise or end to end, your choice.