Oh gee, what weapon to use...
Autoloader 12gauge?
Semi-auto .308?
Ar15 with frangible loads?
Twin Ruger 10-22 motor driven gatling gun, yes there is such a thing. Electric motor though has to be custom mounted to trigger.
I’d use autoloader 12 gauge as most of this crap you see will be close range... sling the semi-auto 308 for any ranged work.
I like my AR15, but 308 has much more stopping power.
I hate snakes, the idea of shooting a python and not dropping it scares me to death haha.