Chargers have written the book about how to defend against Manning. Same with Belichick.
Chargers disguise coverages. Belichick gets in his face with pressure. Manning has to feel that he has to score in order to keep up with a solid offense. That’s when he starts forcing throws and the picks come.
Maybe SD, but, not BB. Not anymore. The Colts have won 5 of the last 6 against him.