[neverdem]

The source uses the Greek letters for alpha and gamma, respectively.

Carvacrol, a component of thyme oil, activates PPAR alpha and gamma and suppresses COX-2 expression

Cyclooxygenase-2 (COX-2), the rate-limiting enzyme in prostaglandin biosynthesis, plays a key role in inflammation and circulatory homeostasis. Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors belonging to the nuclear receptor superfamily and are involved in the control of COX-2 expression, and vice versa. Here, we show that COX-2 promoter activity was suppressed by essential oils derived from thyme, clove, rose, eucalyptus, fennel, and bergamot in cell-based transfection assays using bovine arterial endothelial cells. Moreover, from thyme oil, we identified carvacrol as a major component of the suppressor of COX-2 expression and an activator of PPAR alpha and gamma. PPAR-dependent suppression of COX-2 promoter activity was observed in response to carvacrol treatment. In human macrophage-like U937 cells, carvacrol suppressed lipopolysaccharide-induced COX-2 mRNA and protein expression, suggesting that carvacrol regulates COX-2 expression through its agonistic effect on PPAR. These results may be important in understanding the antiinflammatory and antilifestyle-related disease properties of carvacrol.

For type 2 diabetes, Actos and Avandia are PPAR gamma Agonists

FWIW, but don't try any stunts on your own. Check with your doc.

FReepmail me if you want on or off the diabetes ping list.

[thackney]

Thanks for keeping up the ping list.

[GOPJ]

Thanks for the ping.