I had a run in with a pitbull recently, she was a small female about 40 lbs!
She had a death grip on a small mix bred puppy and was intent on killing it!
The only thing I could think of to do was stick my hand down this bitches throat which is what caused it to release!
If you find a person in this same predicament, ram your hand down the beasts throat!

Firearms work. But hammers, knives, boulders, vehicles, baits and large crescent wrenches work, too.
I have heard that before. with your other hand go for the eyes...