1.) Send it to Los Alamos, a Chinese spy will take it away for you and you'll never see it again.
2.) Send it to Hillary Clinton with a post-it note stuck on it that states: “Vince Foster's Journal.”
3.) Send it to Obama, again with a post-it note: “Original Birth Certificate.”
4.) Send it to ACORN, so your dead drive can vote for Obama in 2012.
5.) Send it to the EPA, telling them this drive has an enormous carbon footprint.
6.) Send it to Hamas. It will be donated to the Clinton Library fund and then given back to Hamas by Hillary. Hamas will give it to the Clinton Library fund again, where it will be sent back to Hamas by Hillary. This will cause an infinite loop and nobody will have the time to try to read the data.
7.) Stick a squirt gun handle on it and register it as a “semi-automatic assault pistol.” The ATF will be by to collect it soon.
8.) Give it to NASA to put on their next CO2 satellite.
9.) Declare it as “Capital Gains.”
10.) If all else fails: Of course, nuke it from orbit. It's the only way to be sure.
That's all I can come up with right now.
Please, join the fun!