I have limited experience using Hostsman on Vista, I’ve been using 3.2.70 Beta6 for a couple of month now on Vista Home Premium 64-bit with no problem whatsoever, also have used it on Windows Server 2008 without a problem.
Hostsman also has a full HOSTS file editor that is simple to use, has a search function, and appends user generated notes to HOSTS file entries as needed (using the # annotation).
According to Microsoft, Windows Defender blocks, at startup, programs and services that require UAC confirmation. However, HostsMan, since version 3.0.40, doesn’t request elevated privileges when it starts. Instead, HM starts in a reduced functionality mode, which can be elevated later by user request, and that’s when you should get an UAC prompt.
And if anything weird happens, you can add the -s argument to the startup command to start Hostsman in reduced privileges mode to avoid the dreaded UAC
“C:\Program Files (x86)\abelhadigital.com\HostsMan\hm.exe” -s
kewl. I’ll have to check into it.