JS- I don’t have the time to go through that site line by line to refute his simplistic oversimplifications of a process he calls ‘remarkably simple’ but hten goes on to explain incredible complexities which he juts glosses over as though they were insignificant when comparing land dwelling clotting systems to jawless fish clotting systems. I’ll take a few lines now, but really- the whole article is a slight-of-hand oversimplification of somethign that Miller himself doesn’t care to address as intellectually honestly as he knows he should.
[[This causes no problem for the organism - most pancreatic proteases are inactive until a small piece near their active sites can be cut away by another protease. However, when damage to a blood vessel allows plasma to seep into tissue, suddenly our previously inactive plasma serine protease is activated by tissue proteases,]]
Abnd htis ALL happens within the species specific parameters for which the species is predesigned to handle- what Miller leaves out is that the new duplicate genes he ASSUMES were created sometime in hte past, they had to have NON SPECIES SPECIFIC infromaiton and structures in order to ‘create’ a complex clotting system not specific to the species.
[[That plasma protease gene is now subject to the same witches’ brew of copying errors, rearrangements, and genetic reshuffling that affect the genes for every other cellular protein. Over time, bits and pieces of other genes are accidentally spliced into the plasma protease sequence.]]
Does miller ever give you proof that htis happened? Or that it could even be possible? No- He simply asserts that it ‘could have happened’- again, oversimplifying hte whole process and making it seem as though htere are no obstrucitons, when hte reality is that DESPITE the fact that species systems can have gene duplicatiosn that were innactive and CAN be demonstrated, are al lspecies specific, and fall within the species specific parameters, and hterefore are not cast off- however, this process he is asserting could have happened invovled process’ that were foriegn to the species, and involve a process of ‘accidental splicings’ that would alter the duplications even further, making htem even more complicated and detrimental to the system while they are innactive.
[[But one day, through a well-understood process called “exon shuffling,” a DNA sequence known as an “EGF domain” is spliced into one end of the protease gene.]]
Gee- what a swell fairy tale- then the princess kissed the frog, and wallah- he became a prince. Any evidence for this? Any evidence that it wouldn’t infact harm instead of being ‘benificial’ as Miller asserts? Nope- not a shred- just wild assumptions.
[[Once we have a situation in which every hemorrage activates a protease bound to tissue receptors, a gene duplicate of one of the major plasma proteins would then be under strong selective pressure to increase its ability to interact with the bound protease.]]
After weaving his incredible fairytale, he then asserts that ‘once everythign is’ miraculously ‘inplace, why then the creature woudl be under great pressure to improve upon this innadequate system. Really? And it would know how to ready itself for new specific mutaitons how? Foresight? Foreknowledge? Hindsight? Miller makes it sound as though nature has soem kind of intelligence, and can foresee that the new clotting system is not up to hte job, and ‘needs improvements’
Cripes- Talk abotu a nonsense faith based scenario!
As I said- the whoel article is full of this nonsense that IGNORES the complexities involved i nthe whole supposed process of evolution of hte clotting system- Miller deceives the reader into thinking it’s a ‘remarkably simple prcoess’ when hte REALITY is that it is no such hting- it invovles processes and reactiosn that can NOT be screwed with without SERIOUS reprocussions to the species- Miller HIDES these FACTS from the reader-
Again- you’re welcoem to your beleif- but let’s not pretend Miller explains how clotting arose, and let’s not pretend that ‘simpler versions’ are the SAME versions as land dwelers- because htey are not- they are compeltely different, and it woudl have taken complete restructuring, and megaevolutionary leaps that nature has NO explaination for how htey could come about. I’m working for a bit, then I’ll be taking a look at an article a member has asked me to look at- so I’m not goign to spend all day on Miller’s nonsense- I just picked a couple random paragraphs, and they are nothign but problem excusing hypothesis’ that are NOT based in reality