The question is, how many people do you know? And are they evenly spread throughout the country? I posit that even one in 5,000 adult citizens, or about 36,000, who are relatively unknown outside their immediate circle of family and friends, will go unnoticed in the population at large; certainly so outside their home cities or states.
The total could go very high, perhaps to 100K (one in 1800), before the magnitude of it becomes apparent to the population at large, at least a third of whom would react with "good riddance".
It's not outside the realm of possibility. Remember that Ayers et. al. contemplated "eliminating" (killing) 25M "hard-core capitalists".
Ayers numbers were for 30 years ago, it would be higher now.
My guess is they will send people to re-education camps. Those who refuse to go or cause trouble at the camps will be sent home and never seen again.
So to survive one must resist at the onset to re-education.
But when I consider how Americans are today most will just allow themselves to be brainwashed. and except family no one will care that people are missing.