It depends on how long and how well you play the real instruments. Both of my now young-adult kids played in the shool orchestra from 3rd through 12th grade. They have an intuitive sense of rhythm, phenomenal hand-eye coordination, and even an understanding of song structure.
Wow... I played piano for at least 12 years by now, and I’m learning acoustic guitar, and while I have a great understanding of theory and song structure and all that, I completely lack any sense of rhythm or hand-eye coordination (or any coordination at all), so Guitar Hero is sort of like learning an entirely new instrument for me. However, my siblings who do have things like coordination and a sense of rhythm, are absolutely great at it.