PCLinuxOS is really nice (using it right now), although I usually use Mepis. I installed it on a no-name computer I bought at Frys (it was their linux computer, running Linspire). After I installed PCLinuxOS, I left it sitting unused for a few months. When I finally fired it up again yesterday, there were over 100 updates available, including some critical core components. I thought, if this doesn't wreck things, I'll be impressed. Well, to my surprise, it *didn't* wreck anything, and it still runs fine!
I installed my network printer without too much problem, and I installed Wine to run my favorite image viewer, Irfanview. So far, so good.
The one thing that concerns me about PCLinuxOS though, is that it's essentially a one-man operation. What happens if the developer goes away (anyone remember Libranet)?