I have large hands, and could not even hold a Desert Eagle securely, so it has never entered my mind to try and fire one.
They had a S&W "Kodiak bear kit", consisting of a S&W .50 Mag five-shot hugh stainless steel revolver with orange grips, in an orange Pelican case, along with other "bear" necessities. You'd almost need bear-sized paws to handle the revolver.
I've seen that S&W bear kit but not up close, the marketing folks went all out on that one, very impressive package.
I like the single stack mag semi autos, like the Sig 220 or S&W 39-2 the best but can shoot larger ones, such as the Glock 21, without any problems.