I see from your profile that you're in Florida. We have some of the least restrictive CCW laws and I would recommend you get your license if you haven't already.
My wife and I both did, and she how has a S&W .38 airweight and I have a Clock 19. We also have a 12 gauge pump for those special occasions. After Katrina, and given how many storms FL mostly dodged, we felt some personal security was in order.
I carry a Keltec .380 all the time now. Easily fits in my jeans or shorts pocket.
You'll probably get a lot of shotgun recommendations here too.
Make that Glock 19... ;-}
As a matter of fact, I did just get a Mossberg 500 12g pump and so far I like it, LOT'S.
I've had a Beretta U22 Neos .22 but I wouldn't rely on it for protection unless it hit the right spots, otherwise it'd be liable just to get somebody p.o'ed
BTW, what does it take in Florida to get a CCW? Only course I ever had was a hunter safety course years back in Ohio.
My wife also loves her S&W .38 airweight and my primary is a 1911 .45.