These projects concern the folding of the triple helix of collagen. Collagen is a major component of bone, skin, and other organs. It is in fact the most abundant protein in humans, taking a quarter of the protein mass. Collagen has a unique structure consisting of three chains wrapped around each other, hence the name triple helix. Mutations in collagen cause misfolding of the triple helix, leading to diseases such as Osteogenesis imperfecta and Ehlers-Danlos syndrome. We are studying the folding mechanism and how mutations affect it.
Points and deadlines:
p1800 - 77 points, 23 days;
p1801 - 66 points, 20 days;
p1802 - 77 points, 23 days;
p1803 - 69 points, 21 days;
p1804 - 123 points, 35 days;
p1805 - 130 points, 37 days;
p1806 - 19 points, 10 days;
p1807 - 19 points, 10 days;
p1808 - 153 points, 44 days;
p1809 - 153 points, 44 days;
Collagen triple helix
The deadlines referred to (in days) for each protein tells us how long we have to complete a work unit before the work unit is considered "stale", and reissued to another cpu.
Don't worry if you have a system that seldom gets on the internet or is even turned on all that often. Once every two weeks is all that it takes to keep the Stanford server updated on progress.
I started this protein on Saturday about 9:00 pm and *should* finish it Monday about 3:30 pm. Folding will speed up once I go to bed and stop surfing, playing iTunes and running Outlook.
Fasinating!
Until ovrtaxt sent a FReep mail last Sunday, I had no idea what Folding@Home was. Thanks, ot, for the invite!
I have folded tinker core 1163 three times already. Why would it still be a "currently running project"?