Yes, regional differences do occur however, they are still useful for determining worldwide events.
"Dr Mike Baillie, Professor of Palaeoecology in the School of Archaeology and Palaeoecology at Queen's University, Belfast, Northern Ireland, is a leading expert in dendrology, or dating by means of tree-rings. In the 1980s, he was instrumental in building a year-by-year chronology of tree-ring growth reaching 7,400 years into the past."
I've read that the tree-ring records have been extended back to 10k years now.
I have also heard that there is a continuous record of sorts.
Absolutely amazing stuff. The creativity and inventiveness of human scholarly efforts never ceases to astound.
Pinging the expert.