Perhaps Dr. Watson could be a modern surgeon or coroner. And as for Moriarty...well, it's not too far a leap to see who HE'D be working for nowadays. And the idea brings up many intriguing possibilities...
Visitor to Baker Street: Good Day, Mr. Holmes. You were recommended to me by very high authorities..
Holmes: Pleasure, Sir. This is my associate, Dr. Watson, of the coroner's office.
Visitor, extending hand:Pleased, Dr. Watson. My name is Bond, James Bond...
The potential alone gives me chills!